General Medicine


During the course in winter semester of students acquire knowledge about causes of pathological states, molecular, cellular, organ and systemic mechanisms of pathogenesis of major medical syndromes, symptoms, and diseases. Students study the basic clinical terminology, role of genetic and environmental factors in development of the diseases, general mechanisms of disease development. The course starts with studying the typical pathological processes: cell damage, inflammation, fever, disorders of nutrition macro- and microelements’ balance, water and acid-base balance. Later on students acquire knowledge about typical disorders in the blood system and haemostasis. Pathophysiology of digestive system and main neurologic disorders is also taught during the course.

During the course in summer semester of study students study common principles of the pathogenesis of the most important disorders of respiratory, cardiovascular, endocrine systems and kidneys, provided with interpretation of typical clinical case studies. Student learn to analyse role of different risk factors in pathogenesis of atherosclerosis, arterial hypertension, bronchial asthma, COPD, diabetes mellitus, kidney failure and other important medical states, comparing common and different pathways in pathogenesis of these states. Aetiology, pathogenesis and clinical manifestations of life-threatening states (shock, coma, heart/respiratory/kidney failures) are explained together with main principles of diagnostics, treatment and prophylaxis of the disorders. The students are taught to consider the complex relations between causes, dynamics and progress of diseases and to perceive the integrative essence of medicine.

Teachers: Prof. MUDr. Martin Petřek, CSc., Gabriella Cápec, Ph.D., Szergej Cápec, Ph.D.

  • Course distribution: 3rd year, 5th and 6th semester
  • Lectures: 30 hours/semester
  • Exercises: 45 hours in winter, 60 hours in summer
  • Completed by: credit, examination
  • Number of credits: 10

You can download study plans (syllabus): pfyvaa11 (winter), pfyvab11 (summer).

Winter semester: The lectures are held in LLH – Left Lecture Hall. on Mondays, from 11:45 a.m. to 13:15 p.m.

Winter semester: The exercises are held in the seminar room of the Department of Pathophysiology on Thursday:

  • Group C – from 8:00 a.m. to 10:15 a.m.
  • Group A and B – from 10:30 a.m. to 12:45 p.m.

Summer semester: The lectures are held in LLH – Left Lecture Hall. on Mondays, from 13:00 p.m. to 14:30 p.m.

Summer semester: The exercises are held in the seminar room of the Department of Pathophysiology on Wednesday:

  • Group B – from 13:45 p.m. to 16:45 p.m.

and Thursday:

  • Group A – from 7:15 a.m. to 10:15 a.m.
  • Group C – from 10:30 a.m. to 13:30 p.m.

Completed by: Credit; Examination

Credit conditions are as follows:

1)      In accordance with Directive of the dean of the faculty of medicine and dentistry LF-B-18/14, article 7. item 1, Department sets the following limit for absences: 4,5 (WS) or 6 (SS) teaching hours (10%) without apologies. Substitutions are provided at the 15th week of the study.

2)      Credit will be granted upon successful answering 2/3 of questions from the respective term topics in the final test on the computer in the 15th week of the term. To take (or re-take) the Credit final test students must register on STAG.

3)      For students, who were active during the term and in each Midterm test achieved minimum 60% with average score over 2/3 of all tests*, final test will not be mandatory.

4)      There are two possibilities for correction of unsuccessful credit test; after that, at the discretion of the department, opportunity for oral correction with at least two teachers will be considered.

5)      Unpreparedness of the student, i.e. the basic deficit in knowledge of the material discussed in the previous Pathophysiology lessons or crucial deficits from previous subjects, especially Physiology, Biochemistry, Histology, Anatomy, etc., can be a reason for exclusion from the lesson.

* Students have possibility to retake 1 Midterm test during semester, extra bonus of up to 10% of average score can be earned by presenting a topic selected from department list.


The exam begins with a written part on the computer. Registration for the date and time in STAG means the written part of the exam. The oral part of the exam may take place on a same day (morning/afternoon) or during the following day.

The condition for passing the exam is success in both parts of the exam; answering at least 60% of the questions in the writing part of the exam.

You can download topics for the exam from pathological physiology here.