The major objective of the course in summer semester is to provide students of dentistry with knowledge that enables them to understand the causes of pathological states and the molecular, cellular, organ and systemic mechanisms of development of medical syndromes, symptoms, and major diseases. The course starts with studying the typical pathological processes: cell damage, inflammation, fever, disorders of water, ion and acid-base balance. Further on during the course students study pathophysiology of respiratory, cardiovascular system, blood and coagulation. Special attention is provided to manifestations of the systemic diseases in oral cavity, and role of the disorders of oral cavity in aetiology and pathogenesis of the systemic diseases.

During the course in winter semester dentistry students of acquire knowledge about molecular, cellular, organ and systemic mechanisms of pathogenesis of disorders of nutrition, gastrointestinal tract, kidneys, endocrine and nervous system. Pathophysiology of disorders of connective tissues and bones is also discussed. Students study systemic manifestations of abovementioned disorders and emphasis is made on pathogenesis of orofacial changes. Students learn to analyze typical clinical case studies related to dentistry praxis with reference to common principles of aetiology and pathogenesis of diseases.

Teachers: Prof. MUDr. Martin Petřek, CSc., Gabriella Cápec, Ph.D., Szergej Cápec, Ph.D.

  • Course distribution: 2nd and 3rd year, 4th and 5th semester
  • Lectures: 30 hours in 4th semester, 15 hours in 5th semester
  • Exercises: 45 hours/semester
  • Completed by: credit, examination
  • Number of credits: 8

You can download study plans (syllabus): pfyzab11 (summer, 4th semester), pfyzaa12 (winter, 5th semester)

Summer semester

  • The lectures are held on Mondays from 8.00 a.m. to 9.30 a.m., in the weeks 7. – 11. in the room No. 2.517, in the weeks 12. – 18. in the room No. 2.521 and in the weeks 19. – 21. in the room No. 2. 520 (Theoretical Institutes – New Building).
  • The exercises are held on Mondays from 9.45 a.m. to 12.00 a.m., in the weeks 7. – 11. in the seminar room of the Department of Pathophysiology, in the weeks 12. – 18. in the room No. 2.521 and in the weeks 19. – 21. in the room No. 2. 520 (Theoretical Institutes – New Building).

Winter semester

  • The LECTURES are held in the RLH – Right Lecture Hall on Mondays, from 8.00 a.m. to 9.30 a.m. on even weeks of the year, starting from 38th week.
  • The EXERCISES are held in the RLH – Right Lecture Hall on Mondays, from 9.45 a.m., to 11. 15 a.m. on even weeks and from 8.00 to 11.15 on odd weeks of the year.

Completed by: Credit. Examination.

Credit conditions are as follows:

1) In accordance with Directive of the dean of the faculty of medicine and dentistry LF-B-18/14, article 7. item 1, Department sets the following limit for absences: 4,5 teaching hours (10%) without apologies. Substitutions are provided at the 15th week of the study.

2) Credit will be granted upon successful answering 2/3 of questions from the respective term topics in the final test on the computer in the 15th week of the term. To take (or re-take) the Credit final test students must register on STAG.

3) For students, who were active during the term and in each Midterm test achieved minimum 60% with average score over 2/3 of all tests*, final test will not be mandatory.

4) There are two possibilities for correction of unsuccessful credit test; after that, at the discretion of the department, opportunity for oral correction with at least two teachers will be considered.

5) Unpreparedness of the student, i.e. the basic deficit in knowledge of the material discussed in the previous Pathophysiology lessons or crucial deficits from previous subjects, especially Physiology, Biochemistry, Histology, Anatomy, etc., can be a reason for exclusion from the lesson.

* Students have possibility to retake 1 Midterm test during semester, extra bonus of up to 10% of average score can be earned by presenting a topic selected from department list.


The exam begins with a written part on the computer. Registration for the date and time in STAG means the written part of the exam. The oral part of the examination may take place on a same day in the morning/afternoon or during the following day.

The condition for passing the exam is success in both parts of the exam; answering at least 60% of the questions in the writing part of the exam.

You can download topics for the exam from pathological physiology here.